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  • Title: Influence of pharmacological doses of calcitonin on serum osteocalcin concentration in patients with Paget's disease of the bone.
    Author: Mulder H, Schop C, Koster JC.
    Journal: Acta Endocrinol (Copenh); 1989 Jun; 120(6):721-3. PubMed ID: 2786309.
    Abstract:
    The effect of continuous infusion of calcitonin on serum osteocalcin concentration was studied in 14 patients with Paget's disease. In all patients serum osteocalcin was initially increased. Within 24 h calcitonin gradually reduced serum osteocalcin, a marker of osteoblastic activity. This means that inhibition of the function of the osteoclasts by calcitonin results in an inhibition of the osteoblasts within 24 h in patients with Paget's disease.
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