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  • Title: Low wall shear stress is associated with the rupture of intracranial aneurysm with known rupture point: case report and literature review.
    Author: Zhang Y, Jing L, Zhang Y, Liu J, Yang X.
    Journal: BMC Neurol; 2016 Nov 18; 16(1):231. PubMed ID: 27863464.
    Abstract:
    BACKGROUND: Few previous hemodynamic studies demonstrated the detailed features of rupture point of intracranial aneurysms. The hemodynamic simulation for the case that ruptured during angiography was even rare. In the present study, we studied the hemodynamic characteristics of a posterior communicating artery segment aneurysm that ruptured during angiography and detailed the hemodynamic features at the rupture point. CASE PRESENTATION: One 64-years-patient was 60-69 years old and suffered a subarachnoid hemorrhage within 24 h. Standard digital subtraction angiography and three-dimensional (3D) rotational angiography were performed and an 8 mm left posterior communicating artery segment aneurysm was found. The patient had a seizure immediately following 3D angiography for about 40 s and the immediate follow-up angiography showed contrast extravasation from the tip of identified aneurysms. The consequent vital sign of the patient became unstable. Urgent embolization under general anesthesia was planned, but the relatives refused interventional operation considering the high risk of procedure and poor condition of the patient. The computational fluid dynamic (CFD) method was used to evaluate the hemodynamic characteristics at rupture point, and the results showed that the rupture point was associated with markedly low wall shear stress and high oscillatory shear index without flow impingement. CONCLUSIONS: We present a rare case of which the rupture site was identified during angiography. The hemodynamic simulations revealed that the rupture point was associated with markedly low WSS and high OSI without flow impingement. The result may be unique to this particular aneurysm; however, our findings provide insight into the hemodynamics of rupture point.
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