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  • Title: In-vitro activity of FCE 22101 against respiratory tract pathogens with reference to production of beta-lactamases.
    Author: Dornbusch K, Kronvall G, Göransson E, Mörtsell E.
    Journal: J Antimicrob Chemother; 1989 Mar; 23 Suppl C():31-41. PubMed ID: 2786517.
    Abstract:
    FCE 22101 is a new penem with broad antibacterial spectrum, excluding the pseudomonads, and has stability to many beta-lactamases. FCE 22101 and imipenem were very potent against the bacteria studied, including beta-lactamase producing strains, which can be isolated from patients with respiratory tract infections (MIC less than or equal to 8 mg/l). No strains were found to be resistant to FCE 22101. FCE 22101 was rapidly bactericidal and more stable to inactivation by beta-lactamases from Branhamella catarrhalis, Haemophilus influenzae, Enterobacter cloacae and Klebsiella pneumoniae than imipenem and ceftibuten. The other antibiotics tested varied in their activities against the respiratory tract pathogens.
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