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  • Title: In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex.
    Author: Brown-Elliott BA, Philley JV, Griffith DE, Thakkar F, Wallace RJ.
    Journal: Antimicrob Agents Chemother; 2017 Feb; 61(2):. PubMed ID: 27872065.
    Abstract:
    We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of ≤0.008 μg/ml, and 102/103 isolates had MICs of ≤0.015 μg/ml. Bedaquiline has excellent potential for use in patients with MAC infections, although for reasons of its metabolism by the cytochrome P450 system, it should not be given with rifampin.
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