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  • Title: Modification by apomorphine of the circling behaviour in the rat due to unilateral intranigral injection of 1-methyl-4-phenylpyridine (MPP+).
    Author: Lange KW.
    Journal: J Toxicol Clin Exp; 1989; 9(1):21-5. PubMed ID: 2787400.
    Abstract:
    Unilateral injection of MPP+ (4 micrograms/1 microliter) into the pars compacta of the substantia nigra in rats induced ipsiversive circling immediately after the injection. Ipsiversive circling was still present 7 days after the injection. Systemic injection of the dopamine agonist apomorphine induced contraversive circling. These results show that MPP+ exerts a powerful neurotoxic action on the nigrostriatal dopaminergic system of the rat. Furthermore, the results suggest that unilateral intranigral administration of MPP+ in the rat may induce supersensitive dopamine receptors in the ipsilateral denervated striatum.
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