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  • Title: Blastogenic responses of human lymphocytes to a streptococcal preparation OK-432 and its fractions.
    Author: Tanaka T, Kaneko Y, Haba F, Katsuta S, Tsutsui K, Tamaki S, Chen DR, Suzuki S, Ueda R, Yamamoto A.
    Journal: J Clin Lab Immunol; 1989 Feb; 28(2):91-6. PubMed ID: 2787407.
    Abstract:
    This study was undertaken to examine the blastogenic responses of PBL to Streptococcal preparation OK-432 and its fractions. The results showed that OK-432 and its fractions, Su-PR and PM, have the mitogenic activity against human lymphocytes. The demonstration that PBL which had been cultured with OK-432 expressed IL-2 receptors and the blastogenic responses of PBL to OK-432 were inhibited by anti-IL-2 antibody suggested that IL-2 and IL-2 receptors might play a central role in OK-432-induced proliferation of human lymphocytes.
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