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  • Title: [A novel phenotype (CD 4+, Leu 7+) in large granular lymphocyte leukemia: a case report].
    Author: Ohno T, Miwa H, Anazawa H, Ikeda T, Kawakami K, Katayama N, Shirakawa S.
    Journal: Rinsho Ketsueki; 1989 Feb; 30(2):222-6. PubMed ID: 2787420.
    Abstract:
    We report a case of a 72-year-old man with large granular lymphocyte (LGL) leukemia. Immunophenotypical analysis of the abnormal cells showed the following results: CD 2+, CD 3+, CD 4+, CD 8-, CD 11+, CD 16-, Leu 7+. These cells had natural killer (NK) activity, responded to PHA and recombinant interleukin-2 (rIL-2), and showed neither helper nor suppressor function in B-cell differentiation. Molecular genetical analysis showed monoclonal rearrangement of T-cell receptor beta-chain gene, indicating they are of T-cell origin. These findings provide information on biological characteristics of normal CD 4+, Leu 7+ cells.
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