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  • Title: Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss.
    Author: Zhdanov VV, Miroshnichenko LA, Udut EV, Zyuz'kov GN, Khrichkova TY, Simanina EV, Sherstoboev EY, Stavrova LA, Agafonov VI, Chaikovskii AV, Minakova MY, Dygai AM.
    Journal: Bull Exp Biol Med; 2016 Nov; 162(1):51-55. PubMed ID: 27878722.
    Abstract:
    The leading role in the regulation of erythropoietic activity of adherent bone marrow cells under conditions of post-hemorrhagic anemia is played by classical MAP kinase pathway (ERK pathway). Erythropoietin is not the decisive factor in the formation of erythropoietic activity of adherent cells. PI3K, MAPK/ERK 1/2, and p38-signaling proteins are not the main regulators of local production of erythropoietin after 30% loss of circulating blood volume.
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