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  • Title: [Langerhans cell histiocytosis and Erdheim-Chester disease, a continuity?].
    Author: Parreau S, Haroche J, Pommepuy I, Emile JF, Bourras JC, Archambeaud F.
    Journal: Rev Med Interne; 2017 Jul; 38(7):482-487. PubMed ID: 27889325.
    Abstract:
    INTRODUCTION: Erdheim-Chester disease and langerhans cell histiocytosis are two rare diseases separate on clinical, radiological and histological aspects. However, several cases involving both entities have been described. OBSERVATION: A 70-year-old man had a central diabetes insipidus, xanthelasmas, retroperitoneal fibrosis and osteosclerosis of the legs suggestive of Erdheim-Chester disease. Bone biopsy showed langerhans cell histiocytosis CD1a positive with the presence of BRAF V600E mutation. The patient was treated with vemurafenib with a good clinical course. CONCLUSION: The literature review finds forty observations linking the two diseases that may suggest a pathophysiological link, especially with the hematopoietic myeloid stem cell CD34+. The term inflammatory myeloid neoplasm was advanced.
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