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  • Title: Prolonged Infusion of Dexmedetomidine in Critically-ill Children.
    Author: Andreolio C, Piva JP, Baldasso E, Ferlini R, Piccoli R.
    Journal: Indian Pediatr; 2016 Nov 15; 53(11):987-989. PubMed ID: 27889726.
    Abstract:
    OBJECTIVE: To describe main indications, doses, length of infusion and side effects related to dexmedetomidine infusion. METHODS: Observational and retrospective study evaluating dexmedetomidine use in pediatric intensive care unit. RESULTS: 77 children received dexmedetomidine infusion longer than 6 hours for mechanical ventilation weaning (32.5%), post- neurosurgery and post-upper airway surgery (24.7%), non-invasive ventilation (13%), refractory tachycardia (6.5%) and other causes (23.3%). After 6 hours of infusion, significant decrease in mean arterial pressure and heart rate was observed in all groups. Six children (8%) required withdrawal of drug because of possible side effects: hypotension, bradycardia and somnolence. CONCLUSION: Dexmedetomidine may be used as sedative in critically ill children without much side effects.
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