These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis.
    Author: Kubota T, Kanai Y.
    Journal: Bull Tokyo Med Dent Univ; 1989 Jun; 36(2):13-8. PubMed ID: 2789110.
    Abstract:
    The occurrence of anti-double stranded(ds) DNA idiotype 2C10 was studied in patients with mixed connective tissue disease (MCTD) and progressive systemic sclerosis (PSS). The 2C10-idiotype was originally identified on a dsDNA-specific monoclonal antibody from a lupus-prone MRL/Mp-lpr/lpr (MRL/l) mouse, and it has been demonstrated to be present in the sera of patients with systemic lupus erythematosus (SLE) as well as MRL/l mice. This study showed that three out of ten patients with MCTD and five out of ten with PSS had higher titers of 2C10-idiotype in their sera than the normal subjects. There was a good correlation between the anti-dsDNA activities and the idiotype levels in MCTD (r = 0.85) but not in PSS (r = -0.38). These results suggest that the 2C10-idiotype-bearing antibodies acquire the dsDNA-binding activity more easily in MCTD than in PSS.
    [Abstract] [Full Text] [Related] [New Search]