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  • Title: Cytotoxic T-cell response to influenza A subunit vaccine in patients with type 1 diabetes mellitus.
    Author: Diepersloot RJ, Bouter KP, van Beek R, Lucas CJ, Masurel N, Erkelens DW.
    Journal: Neth J Med; 1989 Aug; 35(1-2):68-75. PubMed ID: 2789342.
    Abstract:
    The cytotoxic T-cell and humoral immune response to a commercially available influenza A-H1N1 subunit vaccine in 14 patients with type 1 diabetes mellitus was compared with the response in 13 healthy volunteers. Cytotoxic T-cell response to vaccination was poor in both patients and controls. At a calculated 50: 1 effector-target cell ratio, however, significantly more controls than patients showed an increase of over 5% cytotoxic T-cell mediated lysis after vaccination (P less than 0.05). In patients the cytotoxic T-cell response decreased with higher percentages of glycosylated haemoglobin (regression coefficient not equal to 0 with P less than 0.05). No significant difference was found between diabetic patients and control subjects with respect to antibody response after vaccination. Implications for vaccination strategy are discussed.
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