These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis and evaluation of the analgesic and antiinflammatory activities of N-substituted salicylamides.
    Author: Daidone G, Raffa D, Plescia S, Matera M, Caruso A, Leone V, Amico-Roxas M.
    Journal: Farmaco; 1989 May; 44(5):465-73. PubMed ID: 2789625.
    Abstract:
    Some N-heterocyclic salicylamide derivatives were prepared by fusion of phenyl salicylate and heterocyclic amines, whereas other ones were synthesized by ring closure using N-salicyloyl-N'-anthranylhydrazine as starting material. All the compounds were tested for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effects, in order to ascertain if the N-substitution would offer any advantages. Some derivatives were more effective than salicylamide and ulcerogenic activity was variably lowered.
    [Abstract] [Full Text] [Related] [New Search]