These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Novel antibacterial polymeric nanocomposite for smart co-delivery of anticancer drugs.
    Author: Zakerzadeh E, Alizadeh E, Samadi Kafil H, Mohammad Hassanzadeh A, Salehi R, Mahkam M.
    Journal: Artif Cells Nanomed Biotechnol; 2017 Dec; 45(8):1509-1520. PubMed ID: 27899033.
    Abstract:
    Here a novel antibacterial nanocomposite was developed for combination cancer therapy. The synthesized nanocarrier was characterized by FTIR, 1H NMR, thermogravimetric analysis (TGA), and FESEM-EDX. Its antibacterial activity was assessed by determining minimum inhibitory concentration (MIC) values. Doxorubicin (DOX) and methotrexate (MTX) conjugation with nanocarrier sustained the release of both drugs with apparent pH-triggered manner. Co-administration of DOX with MTX leads to an efficient anticancer performance to MCF7 cell lines verified by qRT-PCR and MTT assay tests. It was concluded that this novel drug delivery vehicle makes antibacterial and anticancer therapeutic processes proceed spontaneously, representing more efficient drug delivery system in nanomedicine. [Formula: see text].
    [Abstract] [Full Text] [Related] [New Search]