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  • Title: Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease.
    Author: Geula C, Mesulam M.
    Journal: Brain Res; 1989 Sep 25; 498(1):185-9. PubMed ID: 2790472.
    Abstract:
    Selective cholinesterase inhibitors such as BW284C51 and iso-OMPA showed that the plaques and tangles of Alzheimer's disease contain acetylcholinesterase and butyrylcholinesterase activity. In comparison to the cholinesterases of the normal brain, the plaque and tangle-bound cholinesterases in Alzheimer's disease display major shifts in optimum pH and inhibitor sensitivity.
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