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  • Title: Expression of actin isoforms and intermediate filament proteins in childhood orbital rhabdomyosarcomas.
    Author: Cintorino M, Vindigni C, Del Vecchio MT, Tosi P, Frezzotti R, Hadjistilianou T, Leoncini P, Silvestri S, Skalli O, Gabbiani G.
    Journal: J Submicrosc Cytol Pathol; 1989 Jul; 21(3):409-19. PubMed ID: 2790729.
    Abstract:
    The diagnosis of orbital rhabdomyosarcoma (RMS) in childhood gives rise to several clinical and anatomo-pathological problems. Antibodies recognizing structural proteins and cytoskeletal components have been shown to increase the diagnostic accuracy of different neoplastic lesions. In this study we examined anatomo-clinically and, where possible, by means of immunohistochemistry and electron microscopy, a series of 14 cases of orbital RMS in childhood. In the 12 cases studied by immunohistochemistry, desmin was always present, although showing variable patterns, and alpha-sarcomeric actin was found in 10 cases. alpha-Smooth muscle actin was always absent. The other markers tested (myoglobin, polyclonal actin, vimentin and enolase) proved unreliable for several reasons. We conclude that antibodies against desmin and alpha-sarcomeric actin are useful for the diagnostic definition of RMS. In addition, immunohistochemical analysis supplies data regarding the degree of tumor differentiation and may be applied to monitor radio- and chemotherapy.
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