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  • Title: Lactate influx and efflux in the 'Streptococcus mutants group' and Streptococcus sanguis.
    Author: Distler W, Kagermeier A, Hickel R, Kröncke A.
    Journal: Caries Res; 1989; 23(4):252-5. PubMed ID: 2790859.
    Abstract:
    Lactate influx was measured in Streptococcus sanguis and in several strains of Streptococcus mutans by comparing the intra- and extracellular distribution of (14C)-lactate. Lactate efflux was followed enzymatically against rising external lactate concentration. The glucose concentration was monitored in the same way. With S. sanguis OMZ 9, lactate was transported into the cells when a high external lactate concentration and a pH gradient were established. The transport rate was approximately 1,000 nmol lactate per minute and milligram protein. No lactate influx could be measured with four strains of the 'S. mutans group' (OMZ 51, 634, T3/13 and NCTC 10449). Metabolizing cells of S. mutans NCTC 10449 were able to transport lactate even against an external lactate concentration of 92 mmol/l at pH = 7. The transport rates ranged from 1,200 to 750 nmol lactate/min mg protein decreasing with increasing external lactate concentration. While an external pH = 9 had little influence on transport, transport rates decreased to 440 nmol/min mg protein at pH = 5.
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