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  • Title: Isolation of novel stilbenoids from the roots of Cyrtopodium paniculatum (Orchidaceae).
    Author: Auberon F, Olatunji OJ, Raminoson D, Muller CD, Soengas B, Bonté F, Lobstein A.
    Journal: Fitoterapia; 2017 Jan; 116():99-105. PubMed ID: 27908799.
    Abstract:
    Four new stilbenoids, named cyrtopodinone (1), cyrtopodinol (2), and coeludols A and B (3-4) were isolated from the roots of Cyrtopodium paniculatum, together with 21 known stilbenoids derivatives (5-25). Their structures were elucidated by comprehensive spectroscopic analysis including extensive 1D and 2D-NMR techniques. The cytotoxic activities of the isolated compounds were tested on human glioblastoma U-87MG cell line with fluorescence-based image cytometry. Only four compounds (18, 19, 22 and 25) displayed moderate cytotoxicity with IC50 values of 45.2, 39.9, 58.2 and 48.0μM, respectively.
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