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  • Title: Array-Based Comparative Genomic Hybridization (aCGH).
    Author: Zhang C, Cerveira E, Romanovitch M, Zhu Q.
    Journal: Methods Mol Biol; 2017; 1541():167-179. PubMed ID: 27910023.
    Abstract:
    Copy number variations (CNVs) in the genomes have been suggested to play important roles in human evolution, genetic diversity, and disease susceptibility. A number of assays have been developed for the detection of CNVs, including fluorescent in situ hybridization (FISH), array-based comparative genomic hybridization (aCGH), PCR-based assays, and next-generation sequencing (NGS). In this chapter, we describe a microarray method that has been used for the detection of genome-wide CNVs, loss of heterozygosity (LOH), and uniparental disomy (UPD) associated with constitutional and neoplastic disorders.
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