These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effect of electrocortical state on cerebral carbohydrate metabolism in fetal sheep.
    Author: Chao CR, Hohimer AR, Bissonnette JM.
    Journal: Brain Res Dev Brain Res; 1989 Sep 01; 49(1):1-5. PubMed ID: 2791258.
    Abstract:
    We measured hemispherical cerebral blood flow and arteriovenous differences across the cerebral cortex for glucose, oxygen, and lactate during the two primary electroencephalographic patterns (high and low voltage) in unanesthetized, near-term fetal sheep. Oxygen consumption was 127 mumol/min/100 g brain in high voltage and was 14% higher in low voltage. Glucose uptake was 19 mumol/min/100 g and was 37% higher in low voltage. Cerebral blood flow was 112 ml/min/100 g and was 29% higher in low voltage. The glucose:oxygen quotient increased from 0.91 in high voltage to 1.08 in low voltage. There was a net lactate efflux of 3.2 mumol/min/100 g during low voltage compared to a net influx of 3.3 mumol/min/100 g in high voltage. During high voltage the fetal brain uses a small amount of lactate for oxidative metabolism. During low voltage, glucose uptake exceeds the oxygen uptake needed for completely aerobic consumption, and a portion of the energy utilized by the brain is produced anaerobically.
    [Abstract] [Full Text] [Related] [New Search]