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  • Title: Lomefloxacin, a new difluoroquinolone: in vitro activity against gram-positive and gram-negative bacteria.
    Author: Hoban D, Grabowski M, Koss J, Weselowski V.
    Journal: Diagn Microbiol Infect Dis; 1989; 12(3 Suppl):77S-82S. PubMed ID: 2791502.
    Abstract:
    The in vitro activity of lomefloxacin, a new difluoro-quinolone, was compared to other antimicrobial agents against a selection of Gram-positive and Gram-negative organisms. Against the Enterobacteriaceae, the lomefloxacin MIC inhibiting 90% of strains was less than or equal to 0.5 micrograms/ml. Ninety per cent of Pseudomonas aeruginosa and Acinetobacter sp. isolates were inhibited at less than or equal to 4 micrograms/ml. All staphylococci including methicillin-resistant organisms were susceptible at 1.0 micrograms/ml. Enterococcus faecalis, Listeria spp., and sero Group B streptococci were more resistant with an MIC90 of 8, 16 and 4 micrograms/ml, respectively.
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