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  • Title: IP3, still on the move but now in the slow lane.
    Author: Leybaert L.
    Journal: Sci Signal; 2016 Nov 08; 9(453):fs17. PubMed ID: 27919025.
    Abstract:
    In this issue of Science Signaling, Dickinson et al show that the intracellular messenger inositol 1,4,5-trisphosphate (IP3), which triggers the release of calcium (Ca2+) from the endoplasmic reticulum, is a slowly diffusing local signal, rather than a rapidly diffusing global one. These findings have implications for the understanding of the mechanisms of Ca2+ wave propagation, especially long-range, cell-to-cell propagating Ca2+ waves.
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