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  • Title: Dyslipidemia according to gender and race: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
    Author: Santos RD, Bensenor IM, Pereira AC, Lotufo PA.
    Journal: J Clin Lipidol; 2016; 10(6):1362-1368. PubMed ID: 27919353.
    Abstract:
    BACKGROUND: There is little information regarding lipid profiles of racially mixed populations. Differently from other Latin American countries, the proportion of African ancestry is much higher in Brazil. OBJECTIVE: Verify whether there are differences in the lipid profile between black and white subjects and if people with mixed ancestry have a pattern more closely resembling whites or blacks. METHODS: A total of 15,105 civil servants aged 35-74 years from the ELSA-Brasil study had their fasting lipid profile determined. Race/skin color was self-reported as white, mixed, black, Asian, or indigenous. Dyslipidemia subtypes were classified as high triglycerides (TG) (≥150 mg/dL), low HDL-C (<40 [men] and <50 [women] mg/dL), and high LDL-C (≥130 mg/dL or ever taking lipid-lowering agents). The adjusted odds ratios (95% confidence interval) for dyslipidemia were calculated for each racial group using white participants as the reference group by logistic regression. RESULTS: Elevated concentrations in LDL-C and TG and low-HDL-C had a lower prevalence in the black group compared with whites after multivariate adjustment including adiposity and socioeconomic status. For women and men, respectively, the odds ratios (95% confidence interval) for high LDL-C are 0.94 (0.89-0.99) and 0.93 (0.87-0.99); for high TG, 0.63 (0.54-0.74) and 0.92 (0.84-1.00); and for low HDL-C, 0.77 (0.66-0.91) and 0.78 (0.64-0.94). The mixed race group presented a pattern of dyslipidemia closer to white than to black subjects. CONCLUSIONS: Blacks in comparison with whites had lipid concentrations that are associated with a lower risk of atherosclerotic cardiovascular disease. The mixed racial group had lipid concentrations closer to the white grouping.
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