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  • Title: [Effect of nitrobenzylthioinosine accumulated by the heart in rats and guinea pigs on the release of adenine nucleotide breakdown products during ischemia and reperfusion].
    Author: Kuz'min AI, Shul'zhenko VS, Medvedev OS, Kapel'ko VI.
    Journal: Fiziol Zh (1978); 1989; 35(4):3-9. PubMed ID: 2792439.
    Abstract:
    The uptake kinetics of nitrobenzyl thioinosine (NBTI), a nucleoside transport inhibitor, was studied in the isolated Langendorf-perfused guinea pig and rat hearts. In rats the rate constant of NBTI uptake was higher and the extent of NBTI accumulation was less than in guinea pig hearts. Heart-accumulated NBTI inhibited the total release of adenine nucleotide degradation products (ANDP) during reperfusion 25 min after global ischemia. The effect was more pronounced in guinea-pig hearts-in accordance with observed higher myocardial concentration of NBTI. Unlike other ANDP, the release adenosine by guinea-pig hearts was unchanged and that by rat hearts increased. In spite of significant NBTI-induced decrease of ANDP losses recovery of contractile function during reperfusion was not observed to improve.
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