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  • Title: Magnesium deficiency affects the pentylenetetrazol-induced convulsions in magnesium-deprived rats.
    Author: Lopiano L, Chelazzi L, de'Sperati C, Tempia F, Strata P.
    Journal: Funct Neurol; 1989; 4(3):229-34. PubMed ID: 2792856.
    Abstract:
    A group of 11 young albino rats was fed with a Mg2+ free diet. After a few days, the animals showed typical signs of Mg2+ deficiency, consisting in skin vasodilation, red conjunctiva and hair loss. Pentylenetetrazol (50 mg/kg i.p.) injected in these rats, 6 and 12 days after the beginning of the diet, elicited a more severe convulsive activity compared with that shown by a control group of 12 rats. These results suggest that a Mg2+ deficiency, though not necessarily responsible for the convulsive activity, may contribute to facilitate an epileptic episode or may lead to more severe convulsions. The possibility of a more powerful activation of the NMDA receptors in Mg2+ deficiency is discussed.
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