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  • Title: Not all chromosome imbalance resulting from the 11q;22q translocation is due to 3:1 segregation in first meiosis.
    Author: Lockwood DH, Farrier A, Hecht F, Allanson J.
    Journal: Hum Genet; 1989 Oct; 83(3):287-8. PubMed ID: 2793173.
    Abstract:
    The constitutional translocation between chromosomes 11 and 22 [t(11;22)(q23.3;q11.2)] is one of the best known rearrangements in the human genome. Hitherto only one type of unbalanced karyotype, namely 47,XX or XY, +der(22) t(11;22)(q23.3;q11.2) was found among offspring of the translocation carriers. This result is the product of a 3:1 segregation at meiosis. We report an alternative unbalanced karyotype. The proband's karyotype is 47,XY,t(11;22)(q23.3;q11.2), +der(22)t(11;22)(q23.3;q11.2)pat. This finding cannot be due to nondisjunction in first meiosis of the translocation carrier.
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