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  • Title: In vitro thymidine uptake and incorporation into thymic and bursal lymphocytes from young hypothyroidic chickens.
    Author: Scott TR, Glick B.
    Journal: Int Arch Allergy Appl Immunol; 1989; 89(4):394-9. PubMed ID: 2793225.
    Abstract:
    Experiments were conducted to evaluate the ability of thymic and bursal lymphocytes from hypothyroidic chicks to take up 3H-thymidine. To produce hypothyroidism, chicks were fed a diet containing thiouracil (0.1%) from day of hatch to 3 weeks of age. At 1, 2 and 3 weeks of age, body weights were significantly lower for hypothyroid chicks, and at 2 and 3 weeks of age, the relative weights of the thymus and bursa were significantly less than those of controls. Furthermore, chicks treated with thiouracil had significantly lower serum concentrations of 3,5,3'-triiodothyronine (T3) and thyroxine (T4). Thymic cells from hypothyroid chicks incorporated less 3H-thymidine at 1 and 3 weeks of age as assessed by liquid scintillation counting and autoradiography. Liquid scintillation counts for labeled bursal cells from hypothyroid chicks were not lower at 1 week of age, but the counts were lower at 3 weeks of age. Autoradiographic studies with bursal cells revealed that 3H-thymidine incorporation was less, but not significantly less, in medium-size lymphocytes from thiouracil-treated chicks at both 1 and 3 weeks of age. Thymidine incorporation into large bursal cells was affected more by thiouracil treatment at 1 than 3 weeks of age.
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