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  • Title: Uveitic Glaucoma: Long-term Clinical Outcome and Risk Factors for Progression.
    Author: Sharon Y, Friling R, Luski M, Campoverde BQ, Amer R, Kramer M.
    Journal: Ocul Immunol Inflamm; 2017 Dec; 25(6):740-747. PubMed ID: 27937076.
    Abstract:
    PURPOSE: To study the long-term clinical outcomes of uveitic glaucoma and to identify risk factors for progression. METHODS: Retrospective study of uveitic glaucoma patients in two tertiary medical centers in 2003-2015. Patient- and disease-related data was retrieved. Clinical parameters and visual fields measured at predetermined time points were recorded. Outcome measures included maintaining intraocular pressure ≤21 mmHg and preserving visual fields. RESULTS: Included were 34 patients (53 eyes), with a mean follow-up of 7 years. Idiopathic anterior uveitis and open-angle glaucoma were most common. In total, 62% of eyes were steroid responders. Higher IOP was associated with posterior synechiae, peripheral-anterior synechiae, steroidal, and immunomodulatory therapy (p<0.05). Glaucomatous field defects developed in 49%, with most showing no progression, despite elevation of cup-to-disc ratio (p<0.05). CONCLUSIONS: Chronic severe uveitis, expressed by structural complications and immunomodulatory therapy, was associated with high IOP and the need for more IOP lowering medications, but was unrelated to glaucomatous damage.
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