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  • Title: Performance of a MALDI-TOF MS-based imipenem hydrolysis assay incorporating zinc sulfate.
    Author: Knox J, Palombo E.
    Journal: Diagn Microbiol Infect Dis; 2017 Mar; 87(3):258-260. PubMed ID: 27939285.
    Abstract:
    A MALDI-TOF MS1-based imipenem hydrolysis assay was modified by adding ZnSO4. This improved detection of metallo-β-lactamase producing strains without compromising detection of other carbapenemase types. Using 129 genetically characterized Gram-negative bacilli, the sensitivity and specificity were 98.5% (95% confidence interval [CI]: 91.9-99.7%) and 100% (95% CI: 94.3-100%), respectively.
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