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  • Title: A clinical study of intravenous immunoglobulin therapy for childhood idiopathic thrombocytopenic purpura.
    Author: Lin DT, Hwu WL, Lin KH, Lin KS.
    Journal: Taiwan Yi Xue Hui Za Zhi; 1989 Mar; 88(3):244-7. PubMed ID: 2794922.
    Abstract:
    Eight children with idiopathic thrombocytopenic purpura, who responded poorly to the conventional therapy or who already had severe side-effects, were treated with high dose intravenous immunoglobulin. Six of the 8 patients already had chronic diseases (disease duration longer than 6 months) when they entered into this study. Six patients had elevated platelet counts greater than 30 x 10(9)/L (the responders) after immunoglobulin induction therapy (2 g/kg immunoglobulin), and the average peak platelet counts were 231 x 10(9)/L. Two short-term pretreated patients were cured, 2 patients were in a drug-free state (platelet counts ranging from 50 to 150 x 10(9)/L), but another 2 responders did not benefit from the maintenance immunoglobulin therapy (0.5 g/kg/dose). From our preliminary results, high dose intravenous immunoglobulin seemed effective in all short-term pretreated and some chronic cases. It is worth trying immunoglobulin therapy when conventional therapies are not satisfactory.
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