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  • Title: Transient, severe periventricular hypodensity after leukemic prophylaxis with cranial irradiation and intrathecal methotrexate.
    Author: Wendling LR, Bleyer WA, Di Chiro G, McIlvanie SK.
    Journal: J Comput Assist Tomogr; 1978 Sep; 2(4):502-5. PubMed ID: 279550.
    Abstract:
    Serial computed tomography (CT) demonstrated complete resolution of severe periventricular hypodensity occurring in a child after receiving prophylaxis for acute lymphocytic leukemia. The resolution of this encephalopathy suggests that early changes of subacute necrotizing leukoencephalopathy are reversible and CT is copable of detecting these early changes.
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