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  • Title: Thrombotic thrombocytopenic purpura: successful treatment unlocks etiologic secrets.
    Author: Schmidt JL.
    Journal: Mayo Clin Proc; 1989 Aug; 64(8):956-61. PubMed ID: 2796406.
    Abstract:
    The cause of platelet agglutination in thrombotic thrombocytopenic purpura has been an enigma. Current evidence indicates that the interaction of platelets with a platelet-aggregating factor or unusually large multimers of factor VIII: von Willebrand factor, or both, may cause the abnormal platelet agglutination. Recent success in the treatment of thrombotic thrombocytopenic purpura with intravenous infusion of immunoglobulin suggests that the abnormal platelet agglutination in thrombotic thrombocytopenic purpura may reflect a deficiency of immunoglobulins that normally inhibit platelet-aggregating factors or large multimers of factor VIII: von Willebrand factor.
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