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  • Title: [Changes in biliary lithogenicity caused by 4 weeks' weight reduction].
    Author: Janowitz P, Swobodnik W, Wechsler JG, Kuhn K, Wenzel H, Wenk H, Ditschuneit H.
    Journal: Leber Magen Darm; 1989 Jul; 19(4):190-5. PubMed ID: 2796564.
    Abstract:
    In 2 of 12 patients (16.6%) cholesterol monohydrate crystals occurred in duodenal bile samples after a 4 weeks fasting period (452 kcal/day). Cholesterol monohydrate crystals could be observed until recently mainly in patients with cholesterol gallstones. Therefore, this finding indicates increased biliary lithogenicity despite a non statistical decrease in CSI from 1.35 +/- 0.35 to 1.19 +/- 0.64. Presumably the increased lithogenicity may be caused by an increased glycoprotein concentration and an improvement in gallbladder contractility. Short time fasting obviously will be a risk factor for the development of gallstones, if weight and metabolic normalisation cannot be achieved.
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