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  • Title: [Immunoscintigraphy of choroid melanoma using monoclonal antibodies].
    Author: Schaling DF, van Kroonenburgh MJ, Borsje RA, Kakebeeke-Kemme HM, Oosterhuis JA, Pauwels EK.
    Journal: Ned Tijdschr Geneeskd; 1989 Aug 19; 133(33):1644-7. PubMed ID: 2797273.
    Abstract:
    A prospective pilot study on immunoscintigraphy with monoclonal antibody fragments against cutaneous melanoma (MoAb 225.28S) was performed in 17 patients with a clinical diagnosis of choroidal melanoma. Monoclonal antibodies against melanoma associated antigen were labelled with 740 mBq (20 MCi) of the radionuclide 99mTc and injected intravenously. Images were made with a gamma camera 6 hours after injection. With a double pinhole collimator radioactivity was counted thrice in both eyes 6 hours after injection. In 6 out of 17 patients (35.3%) the melanoma could be imaged with the gamma camera. With the double pinhole collimator a significantly higher activity was measured in the melanomatous eye in 13 out of 17 patients (76.5%). In four patients a false negative result was obtained. Considering these results immunoscintigraphy may be valuable in ocular melanoma diagnostics but its specific value still has to be assessed.
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