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  • Title: [Comparative effect of apalcillin and other beta-lactam antibiotics against the Bacteroides fragilis group].
    Author: Dusart G, Simeon de Buochberg M, Zuccarelli M, Attisso MA, Willemin C.
    Journal: Pathol Biol (Paris); 1989 Jun; 37(5 Pt 2):523-7. PubMed ID: 2797878.
    Abstract:
    The in vitro activity of apalcillin was compared with those of mezlocillin, piperacillin, cefoxitin, cefotaxime and cefotetan against 50 strains of Bacteroides fragilis group. The minimal concentrations were determined by a microdilution method in Wilkins-Chalgren medium and subculturing on agar. On the basis of MICs and MBCs range, the activity of apalcillin was similar to that of other beta-lactam antibiotics; cefoxitin was slightly more active. The mode MICs were as follow: apalcillin = 16 micrograms/ml, mezlocillin = 8 micrograms/ml, piperacillin = 2 micrograms/ml, cefoxitin = 8 micrograms/ml, cefotaxime = 8 and 32 micrograms/ml, cefotetan = 4 micrograms/ml. All the strains of B. thetaiotaomicron and B. vulgatus were susceptible to the six beta lactam compounds. The MBCs and MICs were similar. Apalcillin had the greatest bactericidal activity.
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