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  • Title: Long non-coding RNA HNF1A-AS1 up-regulation in non-small cell lung cancer correlates to poor survival.
    Author: Ma YF, Liang T, Li CR, Li YJ, Jin S, Liu Y.
    Journal: Eur Rev Med Pharmacol Sci; 2016 Dec; 20(23):4858-4863. PubMed ID: 27981551.
    Abstract:
    OBJECTIVE: Accumulating studies have focused on the role of the newly identified lncRNAs in the tumor. We aimed to investigate the clinical correlation between long non-coding RNA HNF1A-AS (HNF1A-AS1) expression and non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: Real-time polymerase chain reaction (PCR) was employed to detect HNF1A-AS expression in NSCLC tissues and corresponding adjacent tissues. The c2-test was used to compare the clinicopathological characteristics between different groups. Survival analysis was performed using the Kaplan-Meier method. The univariate and multivariate analyses were performed to investigate the prognostic significance of HNF1A-AS for NSCLC. RESULTS: The level of HNF1A-AS was higher in tumor tissues than that in normal tissues (p < 0.01). In addition, HNF1A-AS level was significantly associated with TNM stage (p = 0.002) and Lymph node metastasis (p = 0.005). Kaplan-Meier analysis indicated that a high level of HNF1A-AS expression predicted unfavorable overall survival (p < 0.001). The univariate and multivariate analysis identified HNF1A-AS as an independent poor prognostic factor for overall survival in NSCLC patients (p < 0.05). CONCLUSIONS: These results demonstrated that overexpression of HNF1A-AS might act a poor prognosis indicator in patients with NSCLC.
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