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  • Title: Preparation of 4-halo-3-hydroxyanthranilates and demonstration of their inhibition of 3-hydroxyanthranilate oxygenase activity in rat and human brain tissue.
    Author: Todd WP, Carpenter BK, Schwarcz R.
    Journal: Prep Biochem; 1989; 19(2):155-65. PubMed ID: 2798363.
    Abstract:
    The chemical syntheses of 4-fluoro-, 4-chloro-, and 4-bromo-3-hydroxyanthranilic acids are described. Their actions as inhibitors of 3-hydroxyanthranilate oxygenase in cell-free homogenates from rat and human brain and in rat brain slices are presented.
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