These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hypotheses on the role of prostaglandins in the pathogenesis of epinephrine maculopathy and aphakic cystoid macular edema.
    Author: Miyake K, Shirasawa E, Hikita M.
    Journal: Prog Clin Biol Res; 1989; 312():265-76. PubMed ID: 2798479.
    Abstract:
    This article presents hypotheses regarding pathogenesis of epinephrine maculopathy. According to these hypotheses, two points are the most essential in the development of epinephrine-induced CME: one is the stimulation of PG synthesis by some tissues, presumably, the anterior uvea by the applied epinephrine, the other is the dysfunction, in some aphakic eyes, of the active transport system (Bito's pump) which is responsible for the removal of PGs from intraocular fluids. To test these hypotheses, the authors and their group conducted several experimental studies. The results of these studies, which have been reviewed in this article, strongly suggest that epinephrine maculopathy is induced by a mechanism involving PGs or possibly, other related eicosanoids and not simply by epinephrine per se, as has previously been suggested. This in turn suggest the existence of some common factors in the pathogenesis of epinephrine maculopathy and aphakic or pseudophakic CME.
    [Abstract] [Full Text] [Related] [New Search]