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  • Title: Amiloride reduces maternofetal clearance of sodium across the near-term rat placenta.
    Author: Atkinson DE, Sibley CP, Robinson NR.
    Journal: Q J Exp Physiol; 1989 Jul; 74(4):557-60. PubMed ID: 2798765.
    Abstract:
    The effect of amiloride on unidirectional maternofetal clearance across the perfused placenta has been studied in rats at 21 days gestation. A bolus dose of 1 mg kg-1 followed by an infusion of 0.6 mg h-1 into the maternal circulation caused a significant (P less than 0.02) decrease in 22Na clearance by 8%, whilst having no effect on the clearance of 51Cr-EDTA; a ten times higher dose of amiloride (10 mg kg-1, 6 mg h-1) did not reduce 22Na clearance further. Similar administration of an equivalent volume of saline to control animals showed no effect on either Na+ or Cr-EDTA clearances.
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