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  • Title: Hatching in the sea urchin Lytechinus pictus is accompanied by a shift in histone H4 gene activity.
    Author: Grunstein M.
    Journal: Proc Natl Acad Sci U S A; 1978 Sep; 75(9):4135-9. PubMed ID: 279903.
    Abstract:
    There is a distinct shift in histone mRNA synthesis at approximately 11--12 hr of sea urchin emhryogenesis, coincident with embryonic hatching. The synthesis of the blastula type (early) histone mRNAs gradually ceases at this stage and a new class of posthatching (late) histone mRNAs is produced. Briefly labeled early and late mRNAs were isolated and identified by means of RNA-DNA hybridization to different cloned histone genes. The late histone HI mRNA is approximately 40 nucleotides longer than the early HI mRNA. The H3, H2A, H2B, and H4 late mRNAs are 15--40 nucleotides shorter than their early counterparts. We present sequence evidence to show that the genes coding for the late H4 mRNA are a separate class from those that code for the early histone H4 message.
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