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  • Title: Tumor Necrosis Factor-α and Interleukin-1-β Polymorphisms in Pre-Eclampsia.
    Author: Tavakkol Afshari Z, Rahimi HR, Ehteshamfar SM, Ganjali R, Tara F, Shapouri Moghadam A.
    Journal: Iran J Immunol; 2016 Dec; 13(4):309-316. PubMed ID: 27999242.
    Abstract:
    BACKGROUND: Pre-eclampsia is the most common critical condition during pregnancy. Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant women. OBJECTIVE: To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G-308A), and (G-238A) in pre-eclemptic women in northeastern Iran. METHODS: This study was conducted on 153 pre-eclamptic women (case group) and 150 healthy pregnant women (control group), admitted to Ghaem and Imam Reza hospitals of Mashhad, Iran. IL-1β (C+3954T), TNF- α (G-238A) and TNF-α (G-308A) gene polymorphisms in the promoter region were screened by polymerase chain reaction. Data were analyzed, using SPSS version 16.0. RESULTS: The mean age of the participants in the case and control groups was 28.2 ± 6.1 and 27.1 ± 6.3 years, respectively (P=0.68). The frequency of G-308A polymorphism was significantly higher in the case group, compared to the control group (p<0.001). However, no significant relationship was found between IL-1β genotype and pre-eclampsia (p=0.39). The frequency of TNF- α (G-238A) AA genotype was significantly higher in the case group, while GG genotype was less frequently detected in the case group, compared to the control group (p<0.001 for both genotypes). Moreover, the frequencies of AA genotypes of -238 TNF-α and G-308A polymorphisms were significantly higher in the case group, compared to the control group (p<0.001). CONCLUSION: The significant correlation between inflammation promoting genotypes of TNF-α and pre-eclampsia is noteworthy and provides evidence on the contribution of immune related genes in this disease.
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