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  • Title: Drug-induced progressive multifocal leukoencephalopathy in multiple sclerosis: European regulators' perspective.
    Author: Anton R, Haas M, Arlett P, Weise M, Balabanov P, Mazzaglia G, Prieto L, Keller-Stanislawski B, Raine J.
    Journal: Clin Pharmacol Ther; 2017 Aug; 102(2):283-289. PubMed ID: 28001298.
    Abstract:
    Progressive multifocal leukoencephalopathy (PML) has been associated with the use of a number of multiple sclerosis (MS) immunomodulatory therapies and has assumed a critical place in the evaluation of their benefit/risk. In this review, we discuss the European Union regulatory approach to drug-induced PML in MS, highlight a number of key issues related to the current knowledge on PML, and outline possible paths to help progress the risk management of patients with MS at risk of PML.
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