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  • Title: [11 beta-hydroxylation of 16 alpha-methyl-Reichstein's compound S 21-acetate by Curvularia lunata].
    Author: Huang SH, Xu SW, Fa YH.
    Journal: Wei Sheng Wu Xue Bao; 1989 Feb; 29(1):68-71. PubMed ID: 2800540.
    Abstract:
    The conversion of 16 alpha-methyl-Reichstein's compound S 21-acetate (I) to 16 alpha-methyl-hydrocortisone (II) by the mycelium Curvularia lunata AS3.4381 was studied. Maximal 11 beta-hydroxylating activity of the mycelium was found during cultivation of the microorganism by 24h. Inhibition of the ethanol to the 11 beta-hydroxylating activity was obvious. The yield of 55.4% (II) (W/W) could be achieved during conversion of 0.15% substrate at 72 h.
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