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  • Title: Lymphocyte Subsets in the Adrenal Glands of Dogs With Primary Hypoadrenocorticism.
    Author: Friedenberg SG, Brown DL, Meurs KM, Law JM.
    Journal: Vet Pathol; 2018 Jan; 55(1):177-181. PubMed ID: 28005496.
    Abstract:
    Primary hypoadrenocorticism, or Addison's disease, is an autoimmune condition common in certain dog breeds that leads to the destruction of the adrenal cortex and a clinical syndrome involving anorexia, gastrointestinal upset, and electrolyte imbalances. Previous studies have demonstrated that this destruction is strongly associated with lymphocytic-plasmacytic inflammation and that the lymphocytes are primarily T cells. In this study, we used both immunohistochemistry and in situ hybridization to characterize the T-cell subtypes involved. We collected postmortem specimens of 5 dogs with primary hypoadrenocorticism and 2 control dogs and, using the aforementioned techniques, showed that the lymphocytes are primarily CD4+ rather than CD8+. These findings have important implications for improving our understanding of the pathogenesis and in searching for the underlying causative genetic polymorphisms.
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