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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Wide-field spontaneous Raman spectroscopy imaging system for biological tissue interrogation.
    Author: St-Arnaud K, Aubertin K, Strupler M, Jermyn M, Petrecca K, Trudel D, Leblond F.
    Journal: Opt Lett; 2016 Oct 15; 41(20):4692-4695. PubMed ID: 28005869.
    Abstract:
    Raman spectroscopy has shown great promise as a method to discriminate between cancerous and normal tissue/cells for a range of oncology applications using microscopy and tissue interrogation instruments such as handheld probes and needles. Here we are presenting preliminary steps toward the development of a practical handheld macroscopic Raman spectroscopy instrument, demonstrating its capabilities to discriminate between different biological tissue types during ex vivo porcine experiments. The novel probe design can image a field of view of 25  mm2 with a spatial resolution <100  μm and an average spectral resolution of 95  cm-1, covering the fingerprint region between 450 to 1750  cm-1. The ability of the system to produce tissue maps based on molecular characteristics is demonstrated using a neural network machine learning technique.
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