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  • Title: [Aspects of pathogenesis of "shock lung" in patients with massive blood loss and trauma in the early postresuscitation period].
    Author: Zolotokrylina ES, Vasilenko NI, Morozov NV.
    Journal: Anesteziol Reanimatol; 1989; (3):19-22. PubMed ID: 2802234.
    Abstract:
    116 patients with massive blood loss and trauma have been studied in intensive care units. It has been established that the main reason for the onset of hypoxemia in "shock lung" is disturbed gas exchange in the lungs due to an expanded physiological dead space (VD/VT) and blood shunting in the lungs (QS/QT). Intravascular blood coagulation is one of the main reasons for the development and maintenance of systemic hypoperfusion in the lung tissue. Progressive increase in venous admixture during inhalation of 100% oxygen over a five-day treatment period is due to an increased number of still blood-supplied but already unventilated affected alveoli.
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