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  • Title: Structural and functional state of heart left ventricle depending on polymorphism rs966221 phosphodiesterase 4D gene in emergency workers of the Chornobyl NPP suffering from coronary heart disease.
    Author: Nastina O, Pleskach G, Kursina N, Bazyka O, Makarevich O, Abramenko I, Chumak A, Belyi D.
    Journal: Probl Radiac Med Radiobiol; 2016 Dec; 21():312-335. PubMed ID: 28027560.
    Abstract:
    OBJECTIVE: This study consisted in examination the features of structural and functional state of the cardiovascular system in emergency workers (EW) of the Chernobyl nuclear power plant (ChNPP) who suffered from coronary heart disease (CHD) and having different genotypes due to polymorphism rs966221 phosphodiesterase 4D (PDE4D) gene. MATERIALS AND METHODS: The study involved 121 EW and 63 non irradiated patients with CHD. Standardized survey included echo doppler cardiography (EchoCG) that was done by Diagnostic Ultrasound System DS N3 (Mindray). Polymorphism rs966221 PDE4D determined by polymerase chain reaction followed by restriction reaction products. RESULTS: The distribution of genotypes PDE4D in EW was as follows: CC - 42, CT - 49 and TT - 30 patients. In the con trol group, carriers of the same genotypes were 27, 21 and 15 persons respectively. All echocardiographic parame ters in EW workers and non irradiated patients did not differ significantly. Amongst TT genotype carriers of both groups the proportion of patients with increased myocardial mass index was the highest (82.9%) compared to CC genotype (78.4%) and CT (71.4%). The concentric type of left ventricular (LV) hypertrophy was found in 54.9% of patients with CC genotype, in 51.8% with CT genotype and 45.7% with TT genotype, while the eccentric type in 23.5, 21.4 and 37.1% respectively. The relative number of people with high LV end diastolic volume (EDV) normalized by body surface area (BSA) was 27.5% in CC genotype carriers, 26.8% in CT genotype and 40% in TT genotype carriers (p > 0.05). The increase of BSA indexed LV end systolic volume (ESV) was found in 27.5, 30.4 and 28.6%, and the ejection fraction in 15.7, 23.2 and 22.9% respectively. The largest number of CHD patients with inadequate dias tolic function was in carriers of TT genotype (75%) compared with the data in CC (66.7%) and CT genotypes (42.9%) carriers. CONCLUSIONS: In patients with the same genotype, both EW and non irradiated persons there were virtually no dif ferences in indicators of the structural and functional status of LV. The analysis of changes of LV structure the fol lowing feature was revealed: eccentric type of LV hypertrophy was more common for patients with TT genotype, but concentric type for CC genotype carriers. In one third of patients with CC and CT genotypes and in 40% of TT geno type carriers it was observed LV systolic function disorders. Diastolic dysfunction manifested as often in patients with TT genotype compared with CC and CT genotypes carriers. Meta doslidzhennia poliagala u vyvchenni osoblyvostey̆ strukturno funktsional'nogo stanu sertsevo sudynnoï sys temy v uchasnykiv likvidatsiï naslidkiv avariï (ULNA) na Chornobyl's'kiy̆ atomniy̆ elektrostantsiï (ChAES) z ishemichnoiu khvoroboiu sertsia (IKhS) ta riznymy genotypamy rs966221 gena fosfodiesterazy 4D (PDE4D). Materialy i metody. Obstezheno 121 ULNA z IKhS ta 63 khvorykh na IKhS, iaki ne zaznaly vplyvu ionizuiuchogo vyp rominiuvannia. Standartyzovane obstezhennia vkliuchalo ekho dopplerkardiografichne doslidzhennia (EkhoKG) z vyko rystanniam Diagnostic Ultrasound System DS N3 (Mindray). Polimorfizm rs966221 PDE4D vyznachaly metodom polimeraznoï lantsiugovoï reaktsiï z nastupnoiu restryktsiieiu produktiv reaktsiï.Rezul'taty. Rozpodil genotypiv PDE4D v ULNA buv nastupnym: SS genotyp – 42, ST genotyp – 49 ta TT genotyp – 30 osib. V kontrol'niy̆ grupi nosiiamy tykh zhe genotypiv buly 27, 21 ta 15 osib vidpovidno. Vsi EkhoKG pokaznyky v ULNA ta neoprominenykh khvorykh virogidno ne vidriznialys'. U nosiïv genotypu TT obokh grup chastka khvorykh zi zbil' shenym indeksom masy miokarda bula nay̆vyshchoiu (82,9 %) v porivnianni z genotypom SS (78,4 %) ta ST (71,4%). Kon tsentrychnyy̆ typ gipertrofiï livogo shlunochka zustrichavsia u 54,9 % patsiientiv z genotypom SS, 51,8 % z ST i 45,7 % z TT, a ekstsentrychnyy̆ – u 23,5; 21,4 i 37,1%, vidpovidno. Vidnosne chyslo osib z pidvyshchenym indeksom kintsevogo diastolichnogo ob’iemu u nosiïv genotypu SS bulo 27,5 %, genotypu ST – 26,8 % i genotypu TT – 40% (r>0,05). Zbil' shennia indeksu kintsevosystolichnogo ob’iemu vidznacheno u 27,5; 30,4 i 28,6 %, a znyzhennia fraktsiï vykydu – u 15,7; 23,2 i 22,9 % patsiientiv, vidpovidno. Nay̆bil'sha kil'kist' osib z porushenniam diastolichnoï funktsiï bula sered khvo rykh na IKhS nosiïv TT genotypu (75 %), v porivnianni z danymy pry genotypi SS (66,7 %) i ST (42,9 %).Vysnovky. U khvorykh z odnakovym genotypom, iak ULNA, tak i neoprominenykh osib, praktychno buly vidsutni vidminnosti pokaznykiv, shcho kharakteryzuiut' strukturno funktsional'nyy̆ stan miokarda livogo shlunochka. Pry analizi zmin struktury miokarda livogo shlunochka vidznachena nastupna osoblyvist': u khvorykh z genotypom TT chastishe zustrichavsia ekstsentrychnyy̆ typ gipertrofiï livogo shlunochka, a z genotypom SS – kontsentrychnyy̆. U tre tyny patsiientiv z genotypamy SS i ST sposterigalosia porushennia systolichnoï funktsiï LSh, u nosiïv genotypu TT ïkh chyslo dosiagalo 40 %. Diastolichna dysfunktsiia takozh vyiavlialasia chastishe u patsiientiv z genotypom TT v porivnianni z genotypom SS i ST.
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