These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Impact of arousal threshold and respiratory effort on the duration of breathing events across sleep stage and time of night.
    Author: Wains SA, El-Chami M, Lin HS, Mateika JH.
    Journal: Respir Physiol Neurobiol; 2017 Mar; 237():35-41. PubMed ID: 28040523.
    Abstract:
    PURPOSE: The frequency and duration of breathing events are influenced by sleep stage and time of day. In the present study we examined if these modifications are linked to adaptations in the arousal threshold and/or the magnitude of respiratory effort during and immediately after breathing events. METHODS: Participants with sleep apnea slept for 3h in the evening and morning. For breathing events detected during these sessions the rate of change of respiratory effort, maximum respiratory effort immediately prior to termination of an event, and the maximum tidal volume and the minimum partial pressure of end-tidal carbon dioxide (PETCO2) immediately following an event were measured. RESULTS: The rate of change of respiratory effort was similar in N2 compared to N1 but the maximum respiratory effort immediately prior to event termination was greater (-10.7±1.2 vs. -9.6±1.0cmH2O/s, P<0.05). Likewise, tidal volume was increased (1169±105 vs. 1082±100ml, P<0.05) and PETCO2 was decreased (37.0±0.8 vs. 37.7±0.8mmHg P<0.05) following events in N2 compared to N1. A similar tidal volume and PETCO2 response was evident following events in the morning compared to the evening independent of sleep stage. CONCLUSIONS: We conclude that alterations in the arousal threshold, reflected by an increase in respiratory effort at event termination, coupled to increases in tidal volume and reductions in PETCO2 contribute to modifications in event duration and frequency associated with variations in sleep state or time of night.
    [Abstract] [Full Text] [Related] [New Search]