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  • Title: Psychopathology and plasma cortisol responses to dexamethasone in prepubertal psychiatric inpatients.
    Author: Pfeffer CR, Stokes P, Weiner A, Shindledecker R, Faughnan L, Mintz M, Stoll PM, Heiligenstein E.
    Journal: Biol Psychiatry; 1989 Nov; 26(7):677-89. PubMed ID: 2804189.
    Abstract:
    This study of 51 prepubertal psychiatric inpatients evaluates plasma cortisol measurements at 8 AM, 4 PM, and 11 PM before and after dexamethasone was administered in counterbalanced order at doses of 0.5 mg and 1.0 mg. Approximately 76.5% of the children had an affective disorder. Major depressive disorder was associated with higher plasma cortisol levels than other disorders. Pre- and postdexamethasone plasma cortisol levels using 0.5 mg dexamethasone exhibited a circadian variation. The optimal criterion for cortisol nonsuppression was 5 micrograms/dl measured at 8 AM after administration of 0.5 mg dexamethasone.
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