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  • Title: Association Between Multi-frequency Phase Angle and Survival in Patients With Advanced Cancer.
    Author: Hui D, Dev R, Pimental L, Park M, Cerana MA, Liu D, Bruera E.
    Journal: J Pain Symptom Manage; 2017 Mar; 53(3):571-577. PubMed ID: 28042079.
    Abstract:
    CONTEXT: The ability to predict survival accurately has implications in clinical decision making. OBJECTIVES: We determined the association of phase angle obtained from multi-frequency bioelectric impedance analysis with overall survival in patients with advanced cancer. METHODS: We included consecutive patients with advanced cancer who had an outpatient palliative care consultation. Multi-frequency bioelectric impedance analysis assessed phase angle at three different frequencies (5/50/250 kHz) on each hemibody (right/left). Survival analysis was conducted using the Kaplan-Meier method, log-rank test, and multivariate Cox regression analysis. RESULTS: Among 366 patients, the median overall survival was 250 days (95% confidence interval 191-303 days). The mean phase angle for 5, 50, and 250 kHz were 2.2°, 4.4°, and 4.2° on the right and 2.0°, 4.2° and 4.1° on the left, respectively. For all six phase angles, a lower value was significantly associated with a poorer overall survival (P < 0.001). After adjusting for cancer type, performance status, weight loss, and inflammatory markers, phase angle remained independently associated with overall survival (hazard ratio 0.85 per degree increase, 95% confidence interval 0.72-0.99; P = 0.048). CONCLUSION: Phase angle represents a novel objective prognostic factor in outpatient palliative cancer care setting, regardless of frequency and body sides.
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